5-Hydroxytryptophan (5-HTP) – Thorne

5-HTP is a naturally occurring intermediate in the body’s conversion of the essential amino acid L-tryptophan into serotonin, a neurotransmitter critical for regulating mood, sleep, and appetite.* Supplementing with 5-HTP bypasses the rate-limiting step of tryptophan hydroxylase, which can be impaired by stress, age, insulin resistance, or deficiencies in vitamin C, folate, or iron.

Key Benefits:

• Supports balanced serotonin levels in the central nervous system

• Promotes restful sleep and improved mood*

• Reduces sugar and carbohydrate cravings*

• May alleviate fatigue-related discomfort*

Mechanism:

• 5-HTP is well absorbed orally (≈70% enters the bloodstream) and crosses the blood-brain barrier efficiently.

• Thorne’s formula includes pyridoxal 5'-phosphate (active vitamin B6), the cofactor necessary for converting 5-HTP into serotonin.

Suggested Use:

• Take 1–2 capsules, up to three times daily, or as directed by a healthcare professional.

• Can be taken with meals without reducing effectiveness.

Safety and Warnings:

• Allergy: Avoid if hypersensitive to any ingredients.

• Pregnancy/Nursing: Do not use if pregnant or nursing.

• Interactions: Use caution if taking SSRIs, MAO inhibitors, or other antidepressants due to risk of serotonin excess.

Source: Extracted from the seeds of Griffonia simplicifolia; each lot is tested for contaminants, including being Peak X free.

This supplement is primarily aimed at supporting mood, sleep, and serotonin-mediated appetite regulation.*